When Dean Kittredge is taken on as a hired gun by the Rafter W, the owner's wilful granddaughter, Miss Trashy, is only the first of his worries. He soon finds himself up against the notorious El Serpiente and his gang of Comanchero gunmen. Jensen Crudace, the sinister land and cattle agent, is intent on using the Comancheros to gain control of the territory. Together, Kittredge and ranch foreman Tad Sherman are involved in a desperate quest to track El Serpiente to his hidden base in the heart of a distant mesa. Will they succeed in stopping the ruthless gunmen?