In “Coca and its Therapeutic Application,” Angelo Mariani delves into the multifaceted uses and benefits of coca, a plant with a deep historical and cultural significance in South America. Mariani'Äôs thorough exploration is supported by scientific analysis and anecdotal evidence, presenting coca as a potential remedy for a variety of ailments. His literary style strikes a balance between scholarly rigor and accessible prose, making complex therapeutic concepts digestible for both medical practitioners and laypeople. The work appears against the backdrop of the late 19th century, a period marked by burgeoning interest in natural remedies and the pharmacological potential of indigenous plants, fostering an atmosphere ripe for such exploration. Angelo Mariani was not only a pioneer in the field of pharmacognosy but also a robust advocate for the medicinal properties of coca, informed by his own experiences with the plant. Growing up in an era where traditional medicine was beginning to intersect with emerging scientific understanding, Mariani leveraged his background in medicine and pharmacology to challenge prevailing perceptions of coca. His dedication to empiricism and the emphasis on holistic health underpinned the motivations for writing this influential text, which reflects his synthesis of personal beliefs and scientific inquiry. This book is highly recommended for anyone interested in the intersection of ethnobotany, pharmacology, and the historical use of natural substances in medicine. Mariani'Äôs meticulous research provides vital insights for health professionals, researchers, and enthusiasts of herbal medicine, highlighting the potential of coca in contemporary therapeutic applications. By reading this work, one not only gains knowledge about coca's health benefits but also engages in a dialogue about the ethical implications of its use in modern contexts.