Vomiting can also be caused by intense feelings such as emotional strain, stress, or anxiety. Under normal circumstances, we synthesize the stress-response hormone CRF (corticotropin-releasing factor) in the morning, creating a supply to help face the challenges of the day. CRF helps us tap into energy reserves, prevents the immune system from overreacting, and helps our skin tan as a protective response to stress from sunlight. The brain can also inject an extra portion of CRF into the bloodstream if we find ourselves in a particularly upsetting situation.
However, CRF is synthesized not only by brain cells, but also by gastrointestinal cells. Here, too, the signal is—stress and threat! When gastrointestinal cells register large amounts of CRF, irrespective of where they originate (in the brain or in the gut), the information that one of the two is overwhelmed by the outside world is enough for the body to react with diarrhea, nausea, or vomiting