When a psychic is forced to provide prediction to the mafia in order to keep their crimes from being foiled, Helen Wilson must weigh the balance of her gift with the consequences of now complying with the mob. When an under boss believes she is a threat to their criminal enterprise, he has the psychic killed. Her death causes a physical manifestation of the signs of the Zodiac, who then seek revenge for her murder. The signs then begin a mission of revenge, as each creature targets those involved in the psychics death.