Regulations governing the safe transport of radioactive material have been developed and maintained at the international and national levels for more than six decades. More recently, similar efforts have been initiated for security during the transport of radioactive material; however, safety and security provisions have typically been developed independently. The aim of this publication is to provide technical guidelines and practical information to assist Member States, competent authorities and operators in ensuring an integrated and coordination approach. Based on international good practices, its use will facilitate the management of the interface between nuclear safety and security during normal commercial shipments of radioactive material that pose a low radiological consequence if attacked by an adversary.