Calcium, copper, iron, magnesium, and zinc compete for absorption sites;
taking a single-mineral supplement may lessen the absorption of other
minerals. Thus, for example, calcium supplements should be taken between
meals by people who want to maximize their absorption of iron, magnesium,
and zinc from food.
• When a smaller quantity of calcium, iron, or zinc is consumed, the body
absorbs a higher percentage of the dose, compared to its absorption from a
large quantity. Thus, two 250 mg calcium supplements taken at different
times during the day deliver more calcium than a single 500 mg dose.
• Foods or beverages that accompany mineral intakes can affect absorption
negatively or positively. For example, the amount of iron absorbed can vary
sixfold or more, depending on whether factors that inhibit absorption (such
as cow’s milk, black tea, and wheat bran) or factors that enhance absorption
(such as vitamin C–rich foods) are part of a meal.