Here, the request is sent to the server or the computer’s file system first. While the server opens, reads and returns the data to the client, at the same time the next request is handled by Node.js.
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However, AJAX uses JavaScript to work asynchronously on client-side whereas Node.js uses JavaScript to work asynchronously on server-side.
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Thus, AJAX is used on client-side for asynchronous communication with the server whereas Node.js is used to create a server using JavaScript.